Albany, New York, April 17, 2025 (GLOBE NEWSWIRE) — Ostarine, also known as MK-2866, is a SARM that is considered to be on the milder end of the spectrum and is often used by novices. Many people take this to mean that you do not need to complete the PCT in order to get it,
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This is not what usually happens since there are persons in the world who become repressed on extremely low levels of SARMs merely because their body operates in such a manner that makes them susceptible to the effects of these substances.
Ostarine, contrary to common opinion, lowers your testosterone levels; nevertheless, post-cycle therapy (PCT) is not often required, and your natural testosterone levels will return to normal within a month on their own.
Post-cycle therapies are commonly used by bodybuilders after they have completed a cycle of SARMs or anabolic steroids. The goal of these therapies is to revive lowered endogenous testosterone levels while also increasing testicular size, quality of mood, energy, and the ability to retain gains.
Some people believe that a PCT is unneeded while using Ostarine as a supplement since it is a SARM that is well accepted by both women and men. Nevertheless, natural testosterone levels will decline throughout Ostarine or any other SARM cycle, and users would be prudent to have an efficient PCT program ready to go before beginning a cycle of any SARM.
PCT – An Overview
When an external supply of testosterone is brought within the body, it responds by halting Testosterone synthesis in the testes since there is sufficient of it already there.
The body continually seeks to maintain a good hormonal balance, also called as homeostasis, which is why it responds in this manner.
When the body ceases to produce endogenous testosterone, its progesterone and estrogen and levels climb. Everything is fine while they are taking the SARM or steroid in question, but when they quit, the body has an excess of estrogen and insufficient testosterone to regulate it.
This may result in the emergence of a catabolic condition, in which people begin to lose hard-earned muscle and acquire fat. Their energy drive and energy levels plummet, and they may even suffer sadness.
Gynecomastia is a risk. However, it is not as prevalent as the other issues mentioned above.
This process affects more than just estrogen and testosterone; Energy hormone-binding globulin or SHBG and cortisol levels rise as well.
It is well known that cortisol is terrible for the body since it not only weakens our muscles but also harms our health.
SHBG attaches to testosterone, transferring it and rendering it inactive.
That’s essentially what occurs after your cycle finishes, which is why they developed PCT to assist in reducing the symptoms listed above.
PCT accelerates your body’s return to equilibrium by restoring the imbalance in your HPA axis. As a result, testosterone production restarts.
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Ostarine Decreases Endogenous Testosterone
Because everyone reacts differently to SARMs, despite Ostarine’s well-known mildness, some users may have mild side effects.
If endogenous levels fall considerably, bodybuilders will enter a catabolic state post-cycle, with worsening mood, less energy, and decreased libido.
For people who have not used SARMs ever before, anabolic steroids may see greater decreases in endogenous testosterone after using Ostarine than those whose bodies are already used to PEDs.
Because everyone reacts in different ways to Ostarine, it is suggested that people should have blood tests done before, during, and following a cycle. Such test results will indicate if a PCT is required based on how intensely or acutely endogenous levels change.
It is worth mentioning that if a user does notice minor decreases in natural testosterone from Ostarine, such as HPTA (hypothalamic-pituitary-testicular axis), damage usually returns to normal a few weeks after the cycle (even without a PCT).
How Suppressive is Ostarine?
Ostarine caused a significant decline in testosterone levels in one user, who recorded a pre-cycle of 911 ng/dL and post-cycle of 113 ng/dL. Hypogonadism is defined as a blood level of less than 300 ng/dL. This happened after a 10-week cycle of 20mg in a day, which corresponds to a typical dose of Ostarine cycle.
Another user said that after taking 20-30mg of Ostarine daily for two months, their levels of testosterone reduced from 600 ng/dL to 200 ng/dL.
A case study showed that another user’s testosterone level dropped from 665.70 ng/dL to 207.49 ng/dL after using it for 32 days on a low dose of 5mg/day.
A 23-year-old man saw rapid suppression with Ostarine, with his testosterone decreasing to 137 ng/dL after using 10mg every day for 18 days.
Although there seems to be a general agreement that Ostarine is not very suppressive, anecdotal evidence from multiple users shows severe suppression (60-70%) – even when taking low dosages and purchasing from well-established SARMs vendors.
Ostarine PCT
Users who are suffering mild suppression (30-50%) throughout their cycle might apply the following technique to speed up HPTA recovery.
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Moderate PCT
- Week 1-4: Nolvadex 20mg/day
Users are recommended to begin using Nolvadex right after finishing a cycle, with testosterone levels expected to rebound within 30 days.
Because Nolvadex is a selective estrogen receptor modulator, a SERM, it causes the pituitary gland to release more LH by blocking the effects of estrogen. As a result, this stimulates natural testosterone levels, bringing them back to normal.
Note: In severe circumstances (60-70% decline in testosterone), users may choose 40 mg in a day of Nolvadex for one month or four weeks, albeit this is an aggressive PCT and unneeded for the majority of Ostarine users. If a person is taking 20mg of Nolvadex per day and endogenous levels have not improved after two weeks, an increase to 40mg per day would be useful.
If users have taken Ostarine in a stack with other suppressive SARMs, they may include Clomid and hCG to their stack of PCT — along with Nolvadex — for increased potency.
Clomid raises LH (luteinizing hormone) through the pituitary gland, hence enhancing natural testosterone synthesis.
Human chorionic gonadotropin, HCG, acts as a luteinizing hormone analogue, raising testosterone, spermatogenesis, and testicular hypertrophy.
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Aggressive PCT
Nolvadex—40mg per day (20mg x 2, given continuously for 45 days)
Clomid–100mg/day (50mg x 2, administered continuously for 30 days)
HCG—2000 IU (taken on alternate days for 20 days)
Note: The PCT mentioned above is best for individuals who are substantially shut down (>70% lowered testosterone) and suffering unpleasant side effects, including sadness, lethargy, and lack of libido.
A hormone replacement expert named Dr.Michael Scally devised the above PCT regimen, which he delivered to 19 hypogonadal males in a clinical experiment. Within 45 days, he had restored optimal testosterone functioning to 100% of the males.
Bodybuilders have also utilized this trio of drugs to kick-start their endogenous testosterone production following severe steroid cycles.
How to Prevent the Decrease of Natural Testosterone on Ostarine
Some bodybuilders may use a natural testosterone supplement throughout their Ostarine cycle to compensate for reductions in endogenous testosterone.
As a result, when a user discontinues usage of Ostarine, the levels of testosterone are much more likely to stay within an accepted value.
Users should seek natural testosterone boosters that have many of the following ingredients:
- Ashwagandha
- D-aspartic acid
- Zinc
- Fenugreek
- Ginseng
On the other hand, natural testosterone boosters are unlikely to prevent significant decreases in testosterone if consumers are inherently and genetically susceptible to decreased levels of testosterone due to their reactions to Ostarine. They are, nevertheless, advised as a low-risk strategy to avoid excessive testosterone declines.
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Low Testosterone, No Problem
Ostarine users may not even have low total testosterone levels.
Some Ostarine users have mentioned feeling great after their cycle, only to have blood tests show that they are hypogonadal.
These people have typical energy desires, strong strength when exercising, and good energy and mood.
A condition like this might indicate decreased total testosterone levels but regular free testosterone levels.
Free testosterone is the kind of testosterone that is active and unbound, and it is this testosterone that is really used by the body for the synthesis of new muscle tissue. In this scenario, post-cycle therapy (PCT) may not be necessary since the free testosterone level is the most crucial factor to consider.
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Side Effects
SERMs, the chemicals employed in PCT, have their own adverse effects. Therefore PCT does not come without its poison.
The following are the most prevalent SERM adverse effects:
- Headaches
- Vision issues
- Depression Due to Brain Fog
- ED (Erectile Dysfunction)
- Mood Changes
- Dizziness and chest pain
- Fatigue
- Flashes of heat
While users may not have all of these negative effects all at once, some may be present and may interfere with your daily life.
In the case of Ostarine, if the supplier is reliable and you follow the suggested doses and cycle durations, it is quite unlikely that you will need PCT.
This does not mean that you will not be repressed; it just means that the suppression will not justify the deployment of PCT.
Conclusion
Early anecdotal research reveals that Ostarine could be more suppressive than previously anticipated in certain people, with 60-70% decreases in overall testosterone being quite typical.
To address declines in serum testosterone, Clomid, Nolvadex, and hCG may be administered to expedite HPTA recovery if a testosterone booster is not used on-cycle.
However, such drugs should be explored only if the suppression is considerable (lower than 300 ng/dL), since SERMs may cause adverse effects such as transient headaches, hot flashes, lethargy, and dizziness.
In general, users who choose to conduct a PCT should be dependent on how they feel. A PCT may not be necessary if their testosterone is insufficient, but they feel well. Especially because Ostarine users often retain all their benefits after the cycle, testosterone levels typically rebound within a few days (even without a PCT). However, if the person’s testosterone levels have dropped and they are not feeling good, a PCT ought to be explored.
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Disclaimer: The statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Always consult a healthcare professional before taking any dietary supplements.
Disclosure: This article is for informational purposes only and does not constitute medical advice. The content may include affiliate links, meaning we may earn a commission if you purchase through recommended links. Always consult a healthcare professional before starting any new supplement regimen
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