Tailored for vaccine developers to accurately and reproducibly measure and track COVID-19 specific T-cell response in clinical trials
Powered by T-cell immune response data from over 1,000 COVID-19 patients from ImmuneCODE, the largest public database mapping T-cell receptors (TCRs) to SARS-CoV-2New data demonstrates T-cell response persists beyond 90 daysSEATTLE, Aug. 04, 2020 (GLOBE NEWSWIRE) — Adaptive Biotechnologies (Nasdaq: ADPT) announced today the launch of immunoSEQ® T-MAP
T cells are the adaptive immune system’s first responders to detect any virus. They quickly multiply and circulate in the blood to attack the virus, often before symptoms appear. Among many other jobs, T cells also recruit B cells to produce antibodies after about a week or two to potentially provide immunity against future infection. T cells contain a treasure trove of information that could provide one consistent and trackable measure of the immune response to COVID-19 from initial exposure through viral clearance. T cells can “remember” past infections and kill pathogens if they reappear. Since the decline of antibody signals for SARS-CoV-2 over time has been reported by many researchers, T cells need to be studied to assess how long patients remain resistant to reinfection. Given T cells circulate freely in the blood, they are an easy and thus a desirable target for assessing SARS-CoV-2 exposure and potentially immunity.About ImmuneCODE
ImmuneCODE is an open database that provides a detailed population-level view into the adaptive immune response to the COVID-19 virus. Adaptive Biotechnologies and Microsoft are making these data freely available to any researcher, public health official or organization around the world to accelerate solutions to the global pandemic. The database contains detailed information on the virus-specific T cells as well as the virus-related antigens they recognize. The T-cell responses to these antigens will be tracked across the population to create an immune response signature using thousands of de-identified samples combined from organizations around the globe and ImmuneRACE, the virtual clinical study launched in May to help in the race to find a solution to COVID-19.De-identified blood samples from ImmuneRACE, including patients who were actively infected, recovered or were recently exposed to the virus, are being collected by LabCorp, through its Covance drug development business, using a mobile phlebotomy service. Immune cell receptors from these samples are being sequenced using Illumina platform technology and mapped to virus-specific antigens that are confirmed by Adaptive’s proprietary immune medicine platform to induce an immune response. These study data are being pooled with data from thousands of additional unique de-identified patient samples from many institutions around the world. Using Microsoft Azure’s hyperscale cloud and machine learning capabilities, the accuracy of the immune response will be continuously improved and updated online in real time as more samples are sequenced.* Providence, a large health system with 51 hospitals, including the one near Seattle that treated the first U.S. COVID-19 patient, is an initial clinical collaborator. A sampling of some of our other participating institutions include Institute for Systems Biology (ISB), BloodWorks Northwest, Hospital 12 de Octubre, i+12/CNIO (Madrid, Spain), Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS (Meldola, FC – Italy) / AUSL-Romagna and Department of Experimental, Diagnostic and Specialty Medicine (DIMES), and Università di Bologna (Italy) and the NIH in partnership with ASST Spedali Civil di Brescia, Italy and the University of Milano Bicocca-Fondazione MBBM Ospedale San Gerardo, Monza, Itlay. This list is growing as we continue to work with other investigators globally to collect and sequence valuable patient cohorts. Institutions or collaborators interested in contributing blood samples can direct inquiries to COVID19ImmuneResponse@adaptivebiotech.com.About Adaptive Biotechnologies
Adaptive Biotechnologies is a commercial-stage biotechnology company focused on harnessing the inherent biology of the adaptive immune system to transform the diagnosis and treatment of disease. We believe the adaptive immune system is nature’s most finely tuned diagnostic and therapeutic for most diseases, but the inability to decode it has prevented the medical community from fully leveraging its capabilities. Our proprietary immune medicine platform reveals and translates the massive genetics of the adaptive immune system with scale, precision and speed to develop products in life sciences research, clinical diagnostics, and drug discovery. We have two commercial products, and a robust clinical pipeline to diagnose, monitor and enable the treatment of diseases such as cancer, autoimmune conditions and infectious diseases. Our goal is to develop and commercialize immune-driven clinical products tailored to each individual patient. For more information, please visit adaptivebiotech.com and follow us on www.twitter.com/adaptivebiotech.Forward Looking Statements
This press release contains forward-looking statements that are based on beliefs and assumptions and on information currently available to Adaptive. All statements contained in the press release other than statements of historical fact are forward-looking statements, including statements regarding the ability to map adaptive immune responses to COVID-19, the ability to successfully collect a sufficient number and quality of samples through ImmuneRACE, the ability to efficiently and effectively process data with ImmuneCODE, to leverage any findings or data to advance solutions to diagnose, treat and prevent COVID-19, the ability to develop, commercialize and achieve market acceptance of the Adaptive’s TCR-Antigen Map and other current and planned products and services, research and development efforts. These statements involve risks, uncertainties and other factors that may cause actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements, which are described under “Risk Factors,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and elsewhere in the documents Adaptive files with the Securities and Exchange Commission from time to time.For more information:
Beth Keshishian, Adaptive Media
(917) 912-7195
media@adaptivebiotech.comKarina Calzadilla, Adaptive Investor Relations
Carrie Mendivil, Gilmartin Group
investors@adaptivebiotech.com
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